Greenfield Memorial Lecture
Thursday, September 18, 2014, 5:30pm
Wisconsin Psychiatric Institute and Clinic
6001 Research Park Boulevard, Room 1616 Refreshments will be served.
Rethinking Depression and its Treatment: Insights from Studies of Deep Brain Stimulation
Helen Mayberg, MD
Professor of Psychiatry, Neurology, and Radiology
Dorothy C. Fuqua Chair
Psychiatric Neuroimaging and Therapeutics
Emory University School of Medicine
Helen Mayberg, MD
Helen S. Mayberg, MD heads a multidisciplinary research team studying brain mechanisms mediating depression pathogenesis and antidepressant treatment response using multimodal neuroimaging and pioneered the development of deep brain stimulation for treatment resistant depression. In addition to ongoing studies to develop imaging biomarkers that can optimize treatment selection in individual depressed patients at all stages of illness, the lab is focused on the development of combined structural and electrical connectivity models to optimize surgical targeting, refine stimulation parameters and characterize mechanisms of both immediate and sustained antidepressant effects of high frequency DBS. Combined with real-time behavioral and physiological metrics, these studies offer a unique perspective on critical pathways and mechanisms mediating antidepressant effects of DBS, and on the pathophysiology of treatment resistant depression more generally.
Dr. Mayberg is a Board Certified Neurologist, trained at Columbia's Neurological Institute in New York, with fellowship training in nuclear medicine at Johns Hopkins. She is a member of the Institute of Medicine and is an active participant in a wide variety of advisory and scientific activities across multiple fields in neuroscience.
Holtzheimer, P.E., Kelley, M.E., Gross, R.E., Filkowski, M.M., Garlow, S.J., Barrocas, A., Wint, D., Craighead, M.C., Kozarsky, J., Chismar, R., Moreines, J.L., Mewes, K., Posse, P.R., Gutman, D.A. and Mayberg, H.S., 2012. Subcallosal cingulate deep brain stimulation for treatment-resistant unipolar and bipolar depression. Arch Gen Psychiatry 69, 150-8.
Mayberg, H.S., 2009. Targeted electrode-based modulation of neural circuits for depression. J Clin Invest 119, 717-25.
McGrath, C.L., Kelley, M.E., Dunlop, B.W., Holtzheimer Iii, P.E., Craighead, W.E. and Mayberg, H.S., 2013a. Pretreatment Brain States Identify Likely Nonresponse to Standard Treatments for Depression. Biol Psychiatry.
McGrath, C.L., Kelley, M.E., Holtzheimer, P.E., Dunlop, B.W., Craighead, W.E., Franco, A.R., Craddock, R.C. and Mayberg, H.S., 2013b. Toward a neuroimaging treatment selection biomarker for major depressive disorder. JAMA Psychiatry 70, 821-9.
Nuttin, B., Wu, H., Mayberg, H., Hariz, M., Gabriels, L., Galert, T., Merkel, R., Kubu, C., Vilela-Filho, O., Matthews, K., Taira, T., Lozano, A.M., Schechtmann, G., Doshi, P., Broggi, G., Regis, J., Alkhani, A., Sun, B., Eljamel, S., Schulder, M., Kaplitt, M., Eskandar, E., Rezai, A., Krauss, J.K., Hilven, P., Schuurman, R., Ruiz, P., Chang, J.W., Cosyns, P., Lipsman, N., Voges, J., Cosgrove, R., Li, Y. and Schlaepfer, T., 2014. Consensus on guidelines for stereotactic neurosurgery for psychiatric disorders. J Neurol Neurosurg Psychiatry.
Riva-Posse, P., Choi, K.S., Holtzheimer, P.E., McIntyre, C.C., Gross, R.E., Chaturvedi, A., Crowell, A.L., Garlow, S.J., Rajendra, J.K. and Mayberg, H.S., 2014. Defining Critical White Matter Pathways Mediating Successful Subcallosal Cingulate Deep Brain Stimulation for Treatment-Resistant Depression. Biol Psychiatry.