Greenfield Memorial Lecture

Thursday, September 22, 2016, 5:30pm
Wisconsin Psychiatric Institute and Clinic
6001 Research Park Boulevard, Room 1616
Light refreshments will be served.

Optimizing Sleep-Health with Mindful Awareness Practices: Implications for Depression and Inflammation

Michael R. Irwin, MD

Michael R. Irwin, MD
Cousins Distinguished Professor of Psychiatry and Biobehavioral Sciences,
David Geffen School of Medicine at UCLA
Distinguished Professor of Psychology, UCLA College of Letters and Sciences
Director, Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience
Director, Mindful Awareness Research Center

Dr. Irwin is one of the world’s foremost experts on the psychoneuroimmunological pathways by which psychosocial and behavioral factors influence health and disease. Dr. Irwin has pioneered basic studies to show that activation of receptor dependent mechanisms in the brain play a key role in the integration of the HPA, autonomic, and immune responses to stress. His clinical translational studies were among the first to demonstrate that adrenergic receptor mechanisms steered a reduction in anti-viral immunity and an increase inflammatory responses in older adults and in multiple patient populations (i.e., depression, insomnia, cardiovascular disease, cancer, alcohol use disorders). His research has been supported continuously for over 25 years by his PI leadership of 30 R01 type awards from the NIH. Dr. Irwin is recipient of the Cousins Award for career achievement from the Psychoneuroimmunology Research Society; Excellence in Integrative Medicine Research Award from the European Society of Integrative Medicine; Outstanding Faculty Research Mentor from UCLA; he has served as President for the Academy of Behavioral Medicine Research, American Psychosomatic Society, and the Psychoneuroimmunology Research Society; and was Chairperson of Chairperson, NIH CSR, Mechanisms of Emotion, Stress and Health Study Section.

Suggested Readings

(Irwin 2014, Slavich and Irwin 2014, Black et al. 2015, Irwin et al. 2015, Irwin et al. 2016) Black DS, O'Reilly GA, Olmstead R, Breen EC,Irwin MR (2015). Mindfulness meditation and improvement in sleep quality and daytime impairment among older adults with sleep disturbances: A randomized clinical trial. JAMA Intern Med 175: 494-501.

Irwin MR (2014). Why sleep is important for health: A psychoneuroimmunology perspective. Annu Rev Psychol.

Irwin MR, Olmstead R, Breen EC, Witarama T, Carrillo C, Sadeghi N, Arevalo JM, Ma J, Nicassio P, Bootzin R,Cole S (2015). Cognitive behavioral therapy and tai chi reverse cellular and genomic markers of inflammation in late-life insomnia: A randomized controlled trial. Biol Psychiatry 78: 721-729.

Irwin MR, Olmstead R,Carroll JE (2016). Sleep disturbance, sleep duration, and inflammation: A systematic review and meta-analysis of cohort studies and experimental sleep deprivation. Biol Psychiatry 80: 40-52.

Slavich GM,Irwin MR (2014). From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. Psychol Bull 140: 774-815.

For further information about Dr. Irwin including additional publications, please visit: